Baldridge Lab

Biological Chemistry
University of Michigan Medical School

Current Lab

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Jiwon Hwang

Jiwon Hwang, PhD

Research Investigator

Location: 3200 MSRB3
Lab Phone: (734) 936-3440
Email: jiwonh@med.umich.edu

NCBI Bibliography

Jiwon received her B.S. and M.S in biochemistry from Yonsei University, Seoul in South Korea. Her Master’s work focused on the regulation Cullin E3 ubiquitin ligase in mammalian cells. During her PhD studies with Dr. Rob Kalejta at University of Wisconsin-Madison, her research focused on the mechanisms that mediate viral gene activation during human cytomegalovirus infection as related to ubiquitin/SUMO pathways (2005-2011). For her postdoctoral training, she continued to build on her previous training in ubiquitin by moving into membrane-anchored E3 ubiquitin ligase complex. In the lab of Dr. Ron Kopito at Stanford University, she analyzed Hrd1 ERAD E3 ligase complex using genome-edited Hrd1-TAP knock-in mammalian cell (2011-2014). Due to a family reason, she moved to Baltimore and continued her postdoctoral training in Peter Espenshade’s lab at Johns Hopkins University. She investigated the molecular mechanism of yeast SREBP activation, which led to the identification of Golgi membrane-associated rhomboid Intramembrane protease in addition to the Dsc E3 ubiquitin ligase in the pathway (2014-2017). Her current projects In the Baldridge lab is to identify endogenous Hrd1 substrates and to investigate the properties of Hrd1 using single-molecule approach.

Awards and Honors

  • International Herpesvirus Workshop (IHW) Travel Award, IHW (2010)
  • Vilas Travel Grant, University of Wisconsin-Madison (2010)
  • Peer mentor Award, University of Wisconsin-Madison (2010)
  • Vilas Travel Grant, University of Wisconsin-Madison (2009)
  • Research Fellowship, Protein Network Research Center (PNRC), Korea (2003-2004)
  • Best Poster Award, 59th the Biochemical Society of the Republic of Korea (2002)
  • BK21 Scholarship for graduate training, Korea (2001-2003)
  • Honors Scholarship, Yonsei University, Korea (1998-2000)

Publications

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.

Hwang J, Qi L

Trends in Biochemical Sciences, 2018, 43 (8), 593-605

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Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.

Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR

The Journal of Biological Chemistry, 2017, 292 (22), 9104-9116

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Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2.

Hwang J, Espenshade PJ

The Biochemical Journal, 2016, 473 (16), 2463-9

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A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ

The EMBO Journal, 2016, 35 (21), 2332-2349

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Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle.

Winkler LL, Hwang J, Kalejta RF

Journal of Virology, 2013, 87 (8), 4665-71

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Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication.

Hwang J, Saffert RT, Kalejta RF

MBio, 2011, 2 (2), e00023-11

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Ubiquitin-independent proteasomal degradation during oncogenic viral infections.

Hwang J, Winkler L, Kalejta RF

Biochimica Et Biophysica Acta, 2011, 1816 (2), 147-57

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In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation.

Hwang J, Kalejta RF

Methods (San Diego, Calif.), 2011, 55 (2), 160-5

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Human cytomegalovirus protein pp71 induces Daxx SUMOylation.

Hwang J, Kalejta RF

Journal of Virology, 2009, 83 (13), 6591-8

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Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells.

Hwang J, Kalejta RF

Virology, 2007, 367 (2), 334-8

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TIP120A associates with cullins and modulates ubiquitin ligase activity.

Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB

The Journal of Biological Chemistry, 2003, 278 (18), 15905-10

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TIP120A associates with unneddylated cullin 1 and regulates its neddylation.

Hwang JW, Min KW, Tamura TA, Yoon JB

FEBS Letters, 2003, 541 (1-3), 102-8

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