Baldridge Lab

Biological Chemistry
University of Michigan Medical School

  • Everyone has tried to fit pieces of something they've broken back together to make it work again.  This is one approach we use in our everyday science

    Everyone has tried to fit pieces of something they've broken back together to make it work again. This is one approach we use in our everyday science

  • Our favorite integral membrane protein quality control system

    Our favorite integral membrane protein quality control system

  • Toothless... the workhorse of our lab...

    Toothless... the workhorse of our lab...

  • Proteoliposomes float to the top

    Proteoliposomes float to the top

  • This is home for our yeasty-beasties

    This is home for our yeasty-beasties

  • Our model organism of choice.

    Our model organism of choice.

Protein Quality Control at Cellular Membranes

Our lab focuses on the mechanism by which cells recognize and dispose of misfolded proteins within their organelles. These processes are remarkably conserved, and we use Saccharomyces cerevisiae as a model system, because of its simplicity relative to "higher" eukaryotes. Our Research »

Selected Publications

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Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

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Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (5), E358-67

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Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (6), E290-8

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Latest News

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2018.09.04

We’ve had an influx of talented people! Welcome!

Hopefully we can convince them to stay…

PIBS CMB rotation student, Jeff Knupp;

Chem Bio rotation student, Taslima Khan;

Undergraduate student, Jessica Zhang;

Undergraduate student, Tomoe Miyazaki;

Undergraduate student, Celine Rajoulh

2018.01.01

We are interested in motivated scientists and scientists-in-training at all levels!

Please contact Ryan if you are interested in working with us in any capacity to see what options are available.

Affiliations

Support

Damon Runyon Cancer Research Foundation
University of Michigan Biological Sciences Scholars Program
University of Michigan Medical School
National Institutes of General Medical Sciences