Baldridge Lab

Biological Chemistry
University of Michigan Medical School

  • Our favorite integral membrane protein quality control system

    Our favorite integral membrane protein quality control system

  • Toothless... the workhorse of our lab...

    Toothless... the workhorse of our lab...

  • Proteoliposomes float to the top

    Proteoliposomes float to the top

  • This is home for our yeasty-beasties

    This is home for our yeasty-beasties

  • Growth assays for our yeast

    Growth assays for our yeast

Protein Quality Control at Cellular Membranes

Our lab focuses on the mechanism by which cells recognize and dispose of misfolded proteins within their organelles. These processes are remarkably conserved, and we use Saccharomyces cerevisiae as a model system, because of its simplicity relative to "higher" eukaryotes. Our Research »

Selected Publications

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Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

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Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (5), E358-67

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Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (6), E290-8

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Latest News

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2018.04.18

And we are +1 (Brian has joined our group)

He has joined us through PIBS Biological Chemistry. Welcome back!

2018.01.01

We are interested in motivated scientists and scientists-in-training at all levels!

Please contact Ryan if you are interested in working with us in any capacity to see what options are available.

Affiliations

Support

Damon Runyon Cancer Research Foundation
University of Michigan Biological Sciences Scholars Program
University of Michigan Medical School