Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.
Baldridge RD, Rapoport TA
Cell, 2016, 166 (2), 394-407
View on PubMed »-
Have you ever considered how smaller pieces can be assembled into a whole? This is one approach we use in our everyday science
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Our favorite integral membrane protein quality control system
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Toothless... the workhorse of our lab...
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Proteoliposomes float to the top
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This is home for our yeasty-beasties
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Our model organism of choice.
Protein Quality Control at Cellular Membranes
Our lab focuses on the mechanism by which cells recognize and dispose of misfolded proteins within their organelles. These processes are remarkably conserved, and we use Saccharomyces cerevisiae as a model system, because of its simplicity relative to "higher" eukaryotes. Our Research »Selected Publications
View all »Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.
Baldridge RD, Graham TR
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (5), E358-67
View on PubMed »Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.
Baldridge RD, Graham TR
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (6), E290-8
View on PubMed »Latest News
View all »Congratulations to Brian for his selection to the UMich Genetics Training Program!
https://medicine.umich.edu/dept/human-genetics/genetics-training-program
And we are +1 (Brian has joined our group)
He has joined us through PIBS Biological Chemistry. Welcome back!
Ryan selected as a Damon Runyon-Dale F. Frey Breakthrough Scientist!
Thanks to the Damon Runyon Cancer Research Foundation!
damonrunyon.org/for-scientists/awardees/breakthrough
This is a fantastic organization, please consider supporting their groundbreaking work: damonrunyon.org
We are interested in motivated scientists and scientists-in-training at all levels!
Please contact Ryan if you are interested in working with us in any capacity to see what options are available.
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