Baldridge Lab

Biological Chemistry
University of Michigan Medical School

  • Everyone has tried to fit pieces of something they've broken back together to make it work again.  This is one approach we use in our everyday science

    Everyone has tried to fit pieces of something they've broken back together to make it work again. This is one approach we use in our everyday science

  • Liposomes!

    Liposomes!

  • Toothless... the workhorse of our lab...

    Toothless... the workhorse of our lab...

  • Beautiful.

    Beautiful.

  • Our favorite protein quality control system.

    Our favorite protein quality control system.

  • Proteoliposomes float to the top!

    Proteoliposomes float to the top!

  • This is home for our yeasty-beasties

    This is home for our yeasty-beasties

  • Our model organism of choice.

    Our model organism of choice.

  • Proteoliposomes imaged with a single-molecule setup

    Proteoliposomes imaged with a single-molecule setup

  • mScarlet-I purification

    mScarlet-I purification

  • View from the lab

    View from the lab

Protein Quality Control at Cellular Membranes

Our lab focuses on the mechanism by which cells recognize and dispose of misfolded proteins within their organelles. These processes are remarkably conserved, and we use Saccharomyces cerevisiae as a model system, because of its simplicity relative to "higher" eukaryotes. Our Research »

Selected Publications

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Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1.

Peterson BG, Glaser ML, Rapoport TA, Baldridge RD

eLife, 2019, 8

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Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

View on PubMed »

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (5), E358-67

View on PubMed »

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (6), E290-8

View on PubMed »

Latest News

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2020.02.01

Congratulations to Rachel for her NIH F32 fellowship!

2019.10.10

PFD symposium takeover… Brian, Devon, Rachel, and Jiwon

Congratulations to Brian, Rachel, and Jiwon for winning their categories at the poster session!

2019.04.09

Congratulations to Brian for his NSF GRFP award, well deserved!

His CV is building up quickly!

Affiliations

Support

Damon Runyon Cancer Research Foundation
University of Michigan Biological Sciences Scholars Program
University of Michigan Medical School
National Institutes of General Medical Sciences